模擬移動床色譜SMB (simulated moving bed) is a form of preparative chromatography that utilizes multiple columns that act in concert as a single column. Throughput using SMB can be significantly higher than batch or column format. The qualities of Astec^? CHIROBIOTIC^? CSPs that make them ideal for prep, including SMB, are: excellent enantioselectivity, especially for polar and ionic compounds; mobile phase flexibility to maximize sample solubility; versatility for operation in all mobile phases without memory effects; and high column efficiency for high throughput and minimal downstream processing. Especially relevant for prep by SMB, the ruggedness of CHIROBIOTIC^? CSPs enables long-term and reliable operation. The new Astec^? CHIROBIOTIC^? columns for SMB feature particle size and column dimensions chosen for high flow rate and high efficiency. The set of 8 columns have efficiencies that are matched to within 6% RSD. Single columns in 25 cm x 4.6 mm I.D. and 5 cm x 10 mm I.D. dimensions are available for method development and scale-up experiments.